# NIH Reporter #4R01AG058273-03

Neuroinflammatory Mechanisms of Vascular Cognitive Impairment

**Recipient:** Oregon Health & Science University

**Award Amount:** $536,116.00
**Ceiling:** $536,116.00

**Awarded:** September 15, 2026

**Identifier:** 4R01AG058273-03

Research project funded to study neuroinflammatory mechanisms contributing to vascular cognitive impairment, focusing on metabolic syndrome and immune cell infiltration using mouse models.

### Description

This project investigates the role of metabolic syndrome, endothelial soluble epoxide hydrolase (sEH), and immune cell infiltration in cognitive decline, using mouse models and advanced molecular techniques. It aims to elucidate novel mechanisms of age-dependent immune infiltration and neuroinflammation in vascular cognitive impairment, with potential for developing targeted therapies.

[View original record](https://reporter.nih.gov/search/IgE1H2ioLUOz0qmA4MDg0Q/project-details/11463280)