Award
National Heart, Lung, and Blood Institute 1R01HL183880-01
Understanding how SGLT2 inhibitors protect from heart failure
Recipient
University of Pennsylvania, Philadelphia, PA, United States
Award Amount
$765,129.00
Ceiling
$765,129.00
Awarded
May 04, 2026
Identifier
1R01HL183880-01
NIH awarded a research grant to study how SGLT2 inhibitors protect against heart failure by activating PANK and enhancing cardiac CoA metabolism.
Description
This NIH research grant focuses on understanding the effects of SGLT2 inhibitors on cardiac CoA metabolism and fuel utilization, testing the role of cardiac PANK in heart failure protection in vivo, identifying the molecular mechanism of PANK activation by SGLT2 inhibitors, and discovering small molecules targeting PANK without affecting SGLT2.