Award
National Cancer Institute 5R01CA262788-05
Targeting of Doppel-axis to Control Lung Tumor Angiogenesis and Immunity
Recipient
Taslim A. Al-Hilal
Award Amount
$352,275.00
Ceiling
$352,275.00
Awarded
June 05, 2026
Identifier
5R01CA262788-05
NIH/NCI funded research project targeting the protein doppel to selectively inhibit tumor angiogenesis and improve lung cancer treatment efficacy with fewer side effects.
Description
This research project funded by NIH/NCI focuses on tumor angiogenesis and immunotherapy. It aims to elucidate the mechanisms by which the protein doppel promotes tumor growth, evaluate anti-doppel monoclonal antibodies in mouse models, and explore how Dplhi-TECs influence the lung tumor immune microenvironment to develop targeted therapies with fewer side effects.