Award
NIH Reporter #4R01CA292664-03
Tuning KITv CAR T cells for the solid tumor environment
Recipient
Sloan-Kettering Institute for Cancer Research
Award Amount
$1,848,264.00
Ceiling
$1,848,264.00
Awarded
August 10, 2026
Identifier
4R01CA292664-03
This award supports research to improve CAR T-cell therapy for solid tumors by developing modified KITv CAR T cells that enhance cytotoxicity and overcome immunosuppression, aiming to improve treatment outcomes for solid tumor patients.
Description
The project focuses on enhancing chimeric antigen receptor (CAR) T-cell immunotherapy for solid tumors by exploiting IFNγ-mediated cytotoxic mechanisms and adding a PD1 dominant negative receptor to counteract tumor and macrophage mediated immunosuppression. The research involves developing KITv CAR T cells with multiple modifications to improve efficacy and persistence in the tumor microenvironment.