Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK128352-05
B cell-T cell crosstalk in celiac disease
Recipient
University of Chicago
Award Amount
$427,543.00
Ceiling
$427,543.00
Awarded
July 31, 2025
Identifier
5R01DK128352-05
NIH research grant awarded to University of Chicago to study B cell and T cell interactions in celiac disease aiming to identify new therapeutic targets.
Description
This project investigates the role of B lymphocytes in the pathogenesis of celiac disease, focusing on their interaction with T lymphocytes and their potential as therapeutic targets. The study employs unique mouse models to manipulate B cells, gluten-specific T cells, and HLA molecules to assess their contribution to tissue damage and immune response amplification.