Award
National Institute on Aging (NIA) and National Institute of Neurological Disorders and Stroke (NINDS) 4R01AG068997-02
Subchondral Bone Cavities in Osteoarthritis Pain
Recipient
Johns Hopkins University, Baltimore, MD
Award Amount
$620,588.00
Ceiling
$620,588.00
Awarded
August 22, 2024
Identifier
4R01AG068997-02
The award funds research to understand how subchondral bone changes contribute to osteoarthritis pain, focusing on the role of senescent osteoclasts and sensory nerve growth, with the goal of developing targeted pain therapies.
Description
This project aims to elucidate the mechanisms by which subchondral bone contributes to osteoarthritis (OA) pain and to develop targeted therapies to alleviate pain through modulation of bone remodeling and sensory innervation. The study focuses on the role of senescent osteoclasts in inducing subchondral bone cavity and sensory innervation, the elevation of PGE2, and the effect of eliminating senescent osteoclasts and rescuing subchondral bone remodeling on OA pain.