Award
National Institute of General Medical Sciences 5R35GM155282-04
Towards the Design of a Programmable, Isoform-Selective Proteome Editing System
Recipient
University of Pennsylvania
Award Amount
$387,544.00
Ceiling
$387,544.00
Awarded
May 22, 2026
Identifier
5R35GM155282-04
NIH grant awarded to University of Pennsylvania to develop a programmable proteome editing system using AI and protein language models for precise protein targeting.
Description
The project aims to develop a programmable, isoform-selective proteome editing system leveraging peptide-guided enzymes, artificial intelligence, and protein language models. The work includes creating tools for protein degradation and stabilization, mutant-specific targeting, and modification-specific targeting to advance proteome editing applications.