Award
National Institute of Allergy and Infectious Diseases 5R01AI158830-05
Investigating Immune-Microbiome interactions during treatment of Clostridioides difficile with fecal microbiome transplantation
Recipient
University of Pennsylvania, Philadelphia, PA, United States
Award Amount
$468,900.00
Ceiling
$468,900.00
Awarded
February 13, 2025
Identifier
5R01AI158830-05
This NIH grant supports research on immune system interactions with fecal microbiome transplantation to treat Clostridioides difficile infection, focusing on immunoregulatory mechanisms and human immune cell profiling.
Description
The project aims to understand how immune system interactions with fecal microbiome transplantation support the resolution of Clostridioides difficile infection. It involves investigating immunoregulatory mechanisms, particularly CD4+ T-regulatory cells, and innate immune mediators in murine models and conducting longitudinal profiling of human immune cell populations.