Award
NIH Reporter #1R21AI183054-01A1
Formation of a Novel SARS-CoV-2 Nucleocapsid Dimer: Impacts on Viral and Cellular Processes
Recipient
University of Vermont & St. College, Burlington, VT, United States
Award Amount
$438,983.00
Ceiling
$438,983.00
Awarded
July 08, 2025
Identifier
1R21AI183054-01A1
Research project funded by NIAID to study the effects of a SARS-CoV-2 nucleocapsid protein mutation on viral replication and transmission, aiming to understand viral evolution and identify intervention targets.
Description
This project studies mutations in the nucleocapsid protein of SARS-CoV-2 that lead to the formation of a stable protein dimer, which may impact viral growth, infectivity, and transmission. The research focuses on the G215C mutation, which became dominant in the Delta lineage, and involves constructing a virus reverting this mutation to evaluate its effects on viral fitness and transmission.