Award
National Institute on Aging 1R01AG097492-01
Endothelial TLR2/4 signaling in sex dimorphism of pathological angiogenesis and aging
Recipient
Cleveland Clinic Lerner COM-CWRU
Award Amount
$659,309.00
Ceiling
$659,309.00
Awarded
December 12, 2025
Identifier
1R01AG097492-01
The award supports research on how endothelial TLR2 and TLR4 signaling contribute to sex differences in vascular inflammation and aging, using innovative mouse models and pharmacological approaches to understand genetic mechanisms and develop targeted therapies.
Description
This project investigates the role of endothelial TLR2/4 pathways in sex differences in vascular inflammation and aging, utilizing transgenic mouse models, pharmacological Reactive Carbonyl Scavengers (RCS), and proteomics to develop targeted therapeutics. The study aims to elucidate molecular mechanisms underlying sex-dependent differences in endothelial cell functions affecting angiogenesis-driven diseases and aging, focusing on TLR2 and TLR4 pathways as critical regulators of vascular responses and inflammation.