Award
National Institute of General Medical Sciences 1R41GM161305-01
Synthetic circular supercoiled DNA: an alternative to plasmids for the production of lentiviral vectors for cell and gene therapies
Recipient
Chesapeake Genomic Systems LLC
Award Amount
$306,872.00
Ceiling
$306,872.00
Awarded
September 05, 2025
Identifier
1R41GM161305-01
NIH awarded a project to develop scalable synthetic circular supercoiled DNA for lentiviral vector production in gene therapies, with a focus on efficiency and cost-effectiveness.
Description
The project aims to develop an efficient, scalable, and cost-effective in vitro workflow for producing large (>10 kb) supercoiled DNA molecules for use in gene therapy, specifically targeting the lentivirus market segment. The project is funded by NIH and involves collaboration with a commercial partner for validation.