Award
National Cancer Institute 4R01CA265884-04
Polymerase epsilon-based mouse and derived organoid models of intestinal cancer
Recipient
UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX
Award Amount
$987,867.00
Ceiling
$987,867.00
Awarded
August 25, 2025
Identifier
4R01CA265884-04
The award funds the development of mouse and organoid models of intestinal cancer with high mutation rates to better replicate human cancer characteristics for translational research.
Description
This project aims to develop mouse and organoid models of intestinal cancer that incorporate the ultramutator phenotype, which is characterized by high mutation rates similar to human intestinal cancers. The models will be humanized with respect to mutation rate to facilitate translational research.