Award
National Institutes of Health 5R01HL178849-02
Selective B Cell Depletion Using Engineered T Cells As A Curative Treatment For Acquired Thrombotic Thrombocytopenic Purpura
Recipient
University of Pennsylvania
Award Amount
$783,386.00
Ceiling
$783,386.00
Awarded
July 24, 2026
Identifier
5R01HL178849-02
NIH grant awarded to University of Pennsylvania for research on engineered T cells to treat autoimmune Thrombotic Thrombocytopenic Purpura, focusing on selective B cell depletion strategies.
Description
This NIH grant supports research on engineered T cells for the treatment of autoimmune Thrombotic Thrombocytopenic Purpura (iTTP). The project involves developing strategies to selectively deplete pathogenic B cells while sparing protective B cells, with extensive pre-clinical evaluation planned.