# NIH Reporter #5R01AI184285-03

Early interventions at ART initiation to reduce the HIV-1 reservoir and enhance adaptive immune responses

**Recipient:** University of Pennsylvania, Philadelphia, PA, United States

**Award Amount:** $545,816.00
**Ceiling:** $545,816.00

**Awarded:** September 08, 2026

**Identifier:** 5R01AI184285-03

The award supports research on early interventions using broadly neutralizing antibodies at ART initiation to reduce HIV-1 reservoir and enhance immune responses, aiming to guide future HIV cure strategies.

### Description

This project aims to understand the mechanisms underlying the protective effects of early intervention with broadly neutralizing antibodies against HIV at the time of antiretroviral therapy (ART) initiation. The study will analyze immune responses and HIV reservoir modulation to inform future HIV cure strategies.

[View original record](https://reporter.nih.gov/search/0C83gI3MXki4-tEhFD4UKQ/project-details/11413399)