Award
National Institute on Aging 5R00AG071736-04
Targeting H4K20 methylation to rejuvenate aged stem cell epigenome and regenerative function.
Recipient
Not specified
Award Amount
$244,019.00
Ceiling
$244,019.00
Awarded
August 29, 2025
Identifier
5R00AG071736-04
NIH grant awarded to study epigenetic mechanisms in stem cell aging and explore rejuvenation strategies using mouse models and epigenomic techniques.
Description
The project focuses on epigenetic mechanisms of stem cell aging, specifically the role of Kmt5a and H4K20me1. The research involves mouse genetic models, epigenomics techniques like CUT&Tag, and exercise models. The goal is to understand and potentially reverse age-related stem cell dysfunction.