Award
National Institute on Aging 5R01AG054598-09
Astrocytes as governing pathological drivers of neurovascular dysfunction in AD
Recipient
Massachusetts General Hospital, Boston, MA, United States
Award Amount
$511,105.00
Ceiling
$511,105.00
Awarded
March 03, 2026
Identifier
5R01AG054598-09
This NIH-funded project studies astrocytic calcium signaling's role in neurovascular dysfunction in Alzheimer's Disease, aiming to identify new therapeutic targets using advanced imaging techniques.
Description
The project aims to investigate the role of astrocytic calcium signaling in neurovascular unit dysfunction in Alzheimer's Disease (AD), using multiphoton microscopy in mouse models. The study will analyze calcium dynamics, amyloid deposits, vasculature, and neuronal signaling to identify mechanisms of astrocyte pathophysiology and evaluate potential therapeutic targets.