Award
NIH Reporter #5R01AI173341-03
Functional relevance of C. trachomatis trp operon polymorphism
Recipient
University of Nebraska Medical Center, Omaha, NE
Award Amount
$627,069.00
Ceiling
$627,069.00
Awarded
June 16, 2026
Identifier
5R01AI173341-03
This NIH-funded project studies the regulation of the trp operon in Chlamydia trachomatis by the transcriptional repressor YtgR, aiming to understand bacterial adaptation and pathogenicity in host environments with varying iron and indole levels.
Description
The project investigates the regulation of the trp operon in Chlamydia trachomatis, focusing on the role of the transcriptional repressor YtgR in balancing serine utilization between tryptophan synthesis and phosphatidylserine biosynthesis, especially in tissue environments with indole-producing microbiomes. It explores how YtgR's iron-dependent regulation influences gene expression during epithelial cell differentiation and iron starvation conditions.