Award
National Institute of Mental Health 5K00MH138156-05
Modulation of network dynamics across mood states using closed-loop deep brain stimulation for depression
Recipient
University of California, San Francisco
Award Amount
$107,097.00
Ceiling
$107,097.00
Awarded
May 15, 2026
Identifier
5K00MH138156-05
This award funds research to study and optimize deep brain stimulation therapy for treatment-resistant depression by analyzing neural dynamics and cognitive control through human and rodent studies.
Description
The project aims to understand the neural dynamics affected by deep brain stimulation (DBS) and optimize therapy based on electrophysiological markers for treatment-resistant depression (TRD). It involves collecting intracranial recordings, behavioral testing, and stimulation experiments in humans, as well as circuit dissection in rodent models, aiming to improve individualized therapy for depression.