Award
National Institute of Environmental Health Sciences 5R01ES036923-02
Nuclear moonlighting of arsenic metabolic enzymes and reprogramming-resistant epimutations
Recipient
University of California Los Angeles
Award Amount
$605,062.00
Ceiling
$605,062.00
Awarded
December 23, 2025
Identifier
5R01ES036923-02
Research project funded by NIEHS to study arsenic's impact on epigenetic changes and inheritance using mouse embryonic stem cells.
Description
The project investigates how environmental chemicals, specifically arsenic, trigger epigenetic changes that can be inherited. It focuses on the role of metabolic enzymes in the nucleus affecting epigenetic modifications, using a model of germ cell reprogramming with mouse embryonic stem cells.