Award
NIH Reporter #1R21AG104417-01
Rejuvenation of B cells to improve aged fracture healing
Recipient
Duke University
Award Amount
$444,125.00
Ceiling
$444,125.00
Awarded
August 10, 2026
Identifier
1R21AG104417-01
The award funds research to improve bone fracture healing in the elderly by investigating age-related changes in B cells and testing a therapeutic approach using Maresin 1-treated B cells to enhance healing.
Description
This project aims to study the altered secretome of B cells within the fracture callus due to aging and its effect on bone healing. It involves using scRNA sequencing and flow cytometry to analyze B cell populations and IL7R expression, testing treatment with Maresin 1 to rescue IL7R expression, and evaluating if Maresin 1-treated B cells improve fracture healing in aged mice.