Award
NIH Reporter #5R01NS066974-14
Remote effects of focal hippocampal seizures on neocortical function
Recipient
Yale University, New Haven, CT
Award Amount
$463,216.00
Ceiling
$463,216.00
Awarded
January 30, 2026
Identifier
5R01NS066974-14
This award supports research on how focal limbic seizures affect subcortical arousal and neocortical function, using an awake mouse model and advanced techniques to understand mechanisms and develop treatments to restore consciousness during seizures.
Description
The project aims to investigate the network mechanisms of impaired arousal in focal limbic seizures using advanced imaging, electrophysiology, and genetic techniques in an awake mouse model. The goal is to identify key network nodes and neurotransmitter changes to develop treatments that restore consciousness during seizures.