Award
National Institute of Allergy and Infectious Diseases 5R01AI147118-09
Mechanobiology of the immune synapse: signal integration via actin dynamics
Recipient
CHILDREN'S HOSP OF PHILADELPHIA
Award Amount
$413,263.00
Ceiling
$413,263.00
Awarded
November 01, 2024
Identifier
5R01AI147118-09
NIH grant awarded to study the mechanobiology of the immune synapse, focusing on how actin dynamics integrate signals to influence T cell activation and antigen discrimination.
Description
This project seeks to identify the biochemical and mechanical circuits within the TCR signal transduction network that permit the rapid translation of small differences in the physical characteristics of the TCR–pMHC interactions into distinct cellular responses. It focuses on how mechanical force influences T cell activation and the role of actin dynamics in this process.