Award
National Institute on Aging 5P01AG073084-05
Project 2: Cytoplasmic chromatin fragments (CCF) as a driver of liver cancer and target for intervention during aging
Recipient
Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA
Award Amount
$361,442.00
Ceiling
$361,442.00
Awarded
August 25, 2025
Identifier
5P01AG073084-05
This award funds research investigating how cytoplasmic chromatin fragments contribute to liver cancer development during aging, aiming to identify interventions to prevent hepatocellular carcinoma.
Description
The project focuses on the role of cytoplasmic chromatin fragments (CCF) in liver cancer during aging. It explores the molecular mechanisms involving mitochondrial dysfunction, immune signaling, and cellular senescence. The research aims to develop interventions to prevent hepatocellular carcinoma (HCC).