Award
National Institute of Neurological Disorders and Stroke 5R35NS116850-08
Biophysical mechanisms of gating and modulation in voltage-gated ion channel superfamily
Recipient
Washington University, Saint Louis, MO
Award Amount
$985,337.00
Ceiling
$985,337.00
Awarded
May 05, 2026
Identifier
5R35NS116850-08
This NIH research grant focuses on understanding the molecular mechanisms of voltage gating and modulation in voltage-gated ion channels, which are crucial for electrical signaling in the brain, heart, and muscles. The project aims to explore gating polarity, temperature-dependent gating, molecular interactions, and use advanced techniques like structural studies and supercomputing simulations to inform therapeutic development.
Description
The studies proposed will provide critical insights into the mechanisms of modulation of voltage gating in voltage-dependent ion channels involved in electrical excitability in brain, heart, and muscles. Dysfunction causes disorders such as arrhythmias and epilepsies. Understanding these mechanisms will aid in developing new therapeutics.