Award
NIH Reporter #4R01CA281294-03
The Role of CD3z ITAM (Immunoreceptor Tyrosine-Based Activation Motif) diversity in CAR T cell Force and Function
Recipient
Utah State Higher Education System--University of Utah
Award Amount
$1,739,572.00
Ceiling
$1,739,572.00
Awarded
June 26, 2026
Identifier
4R01CA281294-03
NIH awarded a grant to study the role of CD3z ITAM diversity in CAR T cell function to enhance therapy effectiveness and safety.
Description
This NIH grant project focuses on optimizing CAR T cell therapies by studying the diversity of CD3z ITAM sequences to improve CAR T cell function, persistence, and reduce toxicity. The research aims to understand how different ITAM sequences affect CAR signaling and immune activation, potentially leading to better CAR T cell therapies.