Award
National Institute on Aging 5R01AG079513-05
Characterization of how mRNA translation influences reproductive aging
Recipient
UT Southwestern Medical Center
Award Amount
$336,200.00
Ceiling
$336,200.00
Awarded
March 23, 2026
Identifier
5R01AG079513-05
NIH grant awarded to UT Southwestern Medical Center to study the impact of mRNA translation on reproductive aging using Drosophila as a model, focusing on ribosome function and egg quality.
Description
This NIH-funded research project aims to study reproductive aging by characterizing how ribosomes and changes in mRNA translation impact the quality of stored eggs using Drosophila ovary as a model. The project involves genetic and biochemical approaches to analyze changes in mRNA translation machinery with maternal age and during egg storage, and tests whether manipulating ribosome levels and translation rates can prolong egg quality. It also explores the role of the ribosome oxygenase NO66 in egg quality.