Award
National Institute of Allergy and Infectious Diseases 1R21AI200071-01
Identifying host-interacting proteins of Sneathia vaginalis
Recipient
University of Kansas Medical Center, Kansas City, KS
Award Amount
$431,591.00
Ceiling
$431,591.00
Awarded
June 11, 2026
Identifier
1R21AI200071-01
This award funds research to identify surface proteins of the bacterium Sneathia vaginalis that interact with human host cells, which may contribute to its role in infections and adverse pregnancy outcomes. The study uses mass spectrometry and genetic techniques to discover potential therapeutic targets and diagnostic markers.
Description
Sneathia vaginalis is a member of the human normal flora of the vagina and a human pathogen associated with preterm birth, amniotic fluid infections, HPV infection, and cervical cancer. This project aims to identify surface proteins of Sneathia vaginalis that mediate host cell adhesion using mass spectrometry and genetic deletion strains to understand its commensal and pathogenic interactions with the host.