Award
NIH Reporter #5U01CA275310-05
Synthetic lethal targeting of EBV-positive diffuse large B cell lymphomas in persons living with HIV
Recipient
UNIVERSITY OF FLORIDA
Award Amount
$676,145.00
Ceiling
$676,145.00
Awarded
July 24, 2026
Identifier
5U01CA275310-05
Research project awarded by the National Cancer Institute to develop targeted synthetic lethal therapies for EBV-positive diffuse large B cell lymphomas in persons living with HIV, with a funding amount of $676,145 and a project duration from 2022 to 2027.
Description
This project focuses on investigating how EBV uses the JAK-STAT3 pathway to reshape DNA repair mechanisms in EBV+ HIV-DLBCL, aiming to develop targeted synthetic lethal therapies. The project involves cell line studies, xenografts, and patient-derived samples from the NCI AIDS and Cancer Specimen Resource.