Award
National Institute of Allergy and Infectious Diseases 1R01AI196092-01
Decoding the role of Aire-expressing Thetis cells in peripheral self-tolerance
Recipient
Sloan-Kettering Institute for Cancer Research
Award Amount
$616,042.00
Ceiling
$616,042.00
Awarded
February 03, 2026
Identifier
1R01AI196092-01
Research project funded by NIAID to study Aire-expressing Thetis cells in immune tolerance, potentially impacting autoimmune disease and cancer therapies.
Description
This project aims to investigate the role of Aire-expressing antigen-presenting cells, specifically Thetis cells, in peripheral immune tolerance. The research will explore the molecular mechanisms by which these cells regulate self-reactive T cells and promote immune tolerance, with potential implications for autoimmune diseases, transplantation, and cancer.