Award
NIH Reporter #5R21AI187895-02
MSC exosomes as probes for ME/CSF immune cell dysfunction
Recipient
Nova Southeastern University, Fort Lauderdale-Davie, FL, United States
Award Amount
$192,500.00
Ceiling
$192,500.00
Awarded
December 01, 2025
Identifier
5R21AI187895-02
Research project investigating mesenchymal stromal cell-derived exosomes to understand and target immune and metabolic dysfunctions in ME/CFS patients.
Description
The project explores the immunomodulatory and regenerative properties of mesenchymal stromal cell-derived exosomes (exos) in the context of ME/CFS. It aims to investigate the effects of exos on immune cell subsets and mitochondrial function in PBMCs from ME/CFS patients, utilizing co-culture experiments, surface marker analysis, RNA expression profiling, and mitochondrial assessments. The study seeks to uncover novel therapeutic targets and improve understanding of ME/CFS pathology.