Washington State Department of Veterans Affairs BX-22-001

Recruitment of Cerebellar Circuits to Modulate Cognition, Reward and Avoidance of Threat

NIH awarded a research grant to VA Puget Sound Healthcare System to study cerebellar circuits involved in cognition and psychiatric disorders using advanced neuroscience techniques, aiming to develop targeted interventions for Veterans.

Description

This NIH research grant focuses on mapping, characterizing, and manipulating cerebellar circuits and their connections to the ventral tegmental area (VTA) to understand their role in cognition, reward, and avoidance of threat, particularly in Veterans with psychiatric disorders such as PTSD and TBI. The project uses advanced techniques including optogenetics, electrophysiology, and fiber photometry to study these neural circuits and aims to identify potential targets for neuromodulatory, behavioral, or pharmacological interventions.

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