Award
National Institute of Neurological Disorders and Stroke 5R01NS126762-04
Role of mechanical heterogeneity in cerebral aneurysm growth and rupture
Recipient
University of Minnesota, Minneapolis, MN
Award Amount
$491,601.00
Ceiling
$491,601.00
Awarded
December 23, 2025
Identifier
5R01NS126762-04
A research project funded by the National Institute of Neurological Disorders and Stroke to study mechanical heterogeneity in cerebral aneurysms to improve rupture risk prediction through experimental measurements and computational modeling.
Description
This project aims to measure key properties of surgically removed cerebral aneurysms and develop computational models to predict those properties in intact aneurysms, allowing prediction of future tearing to guide clinical management. The study focuses on mechanical heterogeneity's role in aneurysm growth, remodeling, and rupture, using experiments and computational models to improve rupture risk prediction.