Award
NIH Reporter #7K01DK140610-03
Transcriptional regulation of mitochondrial metabolism in human intestinal stem cells
Recipient
North Carolina State University, Raleigh, NC
Award Amount
$108,362.00
Ceiling
$108,362.00
Awarded
August 04, 2026
Identifier
7K01DK140610-03
Research project funded by NIDDK to study transcriptional regulation of mitochondrial metabolism in human intestinal stem cells, focusing on disease mechanisms like inflammatory bowel disease.
Description
The project aims to define novel transcriptional regulators that control mitochondrial dynamics and proinflammatory gene expression in human intestinal stem cells. This research has significant implications for understanding the regulation of intestinal epithelium turnover, metabolism, and mechanisms underlying diseases such as inflammatory bowel disease (IBD). The study involves cross-disciplinary approaches including human tissue culture, genetic engineering, mouse models, metabolomics, and transcription factor analysis.