Award
National Institute on Aging 5R01AG082740-03
VPS13D, organelle contact, and cellular stress in models of disease
Recipient
University of Massachusetts Medical School Worcester, MA
Award Amount
$410,375.00
Ceiling
$410,375.00
Awarded
July 29, 2025
Identifier
5R01AG082740-03
This NIH grant funds research on the role of VPS13D in organelle contact and cellular stress, particularly its impact on mitochondria and ER interactions, autophagy, and inflammation in neurodegenerative disease models.
Description
The project aims to investigate the role of VPS13D in organelle contact, autophagy, stress, and inflammation related to neurodegenerative diseases. The research involves cell and animal models, including patient-derived fibroblasts and knockout mice. The study focuses on the relationship between the lipid transport protein VPS13D, mitochondria and ER contact, autophagy, cell stress, and inflammation in models of a progressive neurodegenerative disease.