Award
National Institute of Allergy and Infectious Diseases 1R01AI189410-01A1
Macrophage senescence as a driver of granuloma failure and progression to necrosis in TB and TB/HIV
Recipient
National Institute of Allergy and Infectious Diseases (NIAID), part of NIH
Award Amount
$3,145,850.00
Ceiling
$3,145,850.00
Awarded
September 19, 2025
Identifier
1R01AI189410-01A1
NIH awarded a grant to study macrophage senescence in TB and TB/HIV, aiming to understand granuloma failure and develop host-directed therapies using advanced techniques and animal models.
Description
This is a NIH grant project focused on studying macrophage senescence in tuberculosis and TB/HIV co-infection, with potential for host-directed therapies. The project involves spatial transcriptomics, drug optimization, and animal models including mice, rabbits, and non-human primates.