Award
National Institute of General Medical Sciences 5R01GM152667-03
Mechanism and Significance of HMG Co-A Synthase 1 Degradation
Recipient
Sloan-Kettering Inst Can Research
Award Amount
$366,810.00
Ceiling
$366,810.00
Awarded
April 02, 2026
Identifier
5R01GM152667-03
Research grant awarded to study the regulation and degradation of HMG-CoA Synthase 1 and its impact on cell metabolism and growth, relevant to cancer and metabolic diseases.
Description
This project investigates the regulation of HMG-CoA Synthase 1 (HMGCS1), the first committed enzyme in the mevalonate pathway, which is critical for cholesterol and non-steroid end product synthesis. The study focuses on how HMGCS1 responds to cellular growth signals, particularly the mTORC1 pathway, and its degradation via the ubiquitin-proteasome system. The research aims to understand how this regulation influences cell proliferation and metabolic demand.