Award
NIH Reporter #5R01AG086251-03
Preservation of muscle function through Schwann cell regulation of motor unit expansion
Recipient
University of Michigan at Ann Arbor, Department of Physiology
Award Amount
$569,854.00
Ceiling
$569,854.00
Awarded
May 26, 2026
Identifier
5R01AG086251-03
A research project funded by the National Institute on Aging to study mechanisms of muscle preservation through Schwann cell regulation, targeting interventions to improve muscle function and quality of life in aging populations.
Description
This research project aims to define cellular responses and molecular pathways critical for motor unit expansion, focusing on the Spp1-CD44-protein kinase C alpha pathway from Schwann cells. The research explores how aging affects this pathway, its role during denervation and reinnervation, and its potential as a therapeutic target to develop protective and rehabilitative therapies for muscle loss.