Award
National Eye Institute 5R01EY036466-03
Modulation of Corneal Endothelial Mitochondrial Activity and Dysfunction by Estrogen
Recipient
Trustees of Indiana University, Bloomington, IN, USA
Award Amount
$423,453.00
Ceiling
$423,453.00
Awarded
June 09, 2026
Identifier
5R01EY036466-03
Research project funded by the National Eye Institute to study the effects of estrogen on corneal endothelial cells using mouse models, aiming to develop new therapies for eye diseases such as Fuchs' Endothelial Dystrophy.
Description
The project aims to determine if estrogen protects or damages corneal endothelial cells, which are vital for maintaining corneal transparency. Estrogen's protective effects on various tissues are well-documented, but its role in corneal endothelium is unclear. The study will use mouse models to assess endothelial function, mitochondrial activity, and oxidative stress, considering sex differences and menopause status. Results could lead to new therapies for eye diseases like Fuchs' Endothelial Dystrophy.