Award
National Institute of Mental Health 5R21MH136489-02
Sex dependent dysregulation of parvalbumin interneurons as a pathway to Autism Spectrum Disorder
Recipient
FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
Award Amount
$209,375.00
Ceiling
$209,375.00
Awarded
August 06, 2025
Identifier
5R21MH136489-02
This NIH grant supports research on how sex-dependent changes in parvalbumin interneurons may contribute to Autism Spectrum Disorder, focusing on epigenetic regulation and network effects in the brain.
Description
Research grant opportunity focused on neurodevelopmental disorders, specifically Autism Spectrum Disorder (ASD). The project involves studying the epigenetic regulation of interneurons in a sex-specific manner to understand mechanisms underlying ASD. The study focuses on the reduction of parvalbumin interneurons in the hippocampus and its impact on network oscillations and ASD-related behaviors, hypothesizing sex-specific epigenetic effects on interneuron maturation contributing to network imbalance in male mice.