Award
NIH Reporter #5K08NS135129-02
Aging-associated changes in the brain's response after a cardiac arrest
Recipient
University of Colorado Denver
Award Amount
$224,424.00
Ceiling
$224,424.00
Awarded
August 13, 2025
Identifier
5K08NS135129-02
A research project funded by the National Institute of Neurological Disorders and Stroke to study age-related brain injury mechanisms after cardiac arrest, focusing on inflammasome pathways in mouse models.
Description
This project investigates the role of inflammasome pathways as molecular mediators of age-related differences in brain injury after global cerebral ischemia induced by cardiac arrest. The study aims to assess age-related differences in inflammasome-mediated inflammation and evaluate how inflammasome activity contributes to neuronal cell loss, synaptic deficits, and cognitive impairment in young and aged mice.