Award
National Institute on Aging 1R21AG092247-01A1
Role of APP-related circRNAs induced by HIV-1 infection in beta-amyloid formation
Recipient
Temple University of the Commonwealth, Philadelphia, PA, United States
Award Amount
$435,875.00
Ceiling
$435,875.00
Awarded
August 06, 2025
Identifier
1R21AG092247-01A1
NIH project studying the role of APP-related circular RNAs in beta-amyloid formation induced by HIV-1 infection, aiming to understand HIV-associated neurocognitive disorders and find new therapeutic targets.
Description
This NIH-funded project investigates the involvement of circular RNAs derived from the APP gene in the formation of beta-amyloid in the context of HIV-1 infection. The study aims to elucidate mechanisms underlying HIV-associated neurocognitive disorders and identify potential therapeutic targets, utilizing advanced in vitro models and molecular techniques.