Award
National Heart, Lung, and Blood Institute 5R01HL153120-05
Role of Monoamine Oxidase A and Diet-Induced Monocyte Dysfunction, Macrophage Reprogramming, and Atherosclerosis
Recipient
Wake Forest University Health Sciences
Award Amount
$587,081.00
Ceiling
$587,081.00
Awarded
March 21, 2025
Identifier
5R01HL153120-05
This NIH grant funds research on the role of Monoamine Oxidase A and diet-induced monocyte dysfunction in macrophage reprogramming and atherosclerosis, aiming to understand molecular mechanisms and identify therapeutic targets.
Description
The project investigates how high-calorie diets induce oxidative stress via Mao A and Nox4, leading to monocyte priming and reprogramming, contributing to atherogenesis. The studies aim to test this paradigm and elucidate the underlying molecular mechanisms related to macrophage dysfunction and atherosclerosis.