Award
National Institute of Allergy and Infectious Diseases 5R01AI191440-02
Dissecting innate immune control of intestinal and systemic Yersinia infection
Recipient
University of Pennsylvania, Philadelphia, PA
Award Amount
$1,038,050.00
Ceiling
$1,038,050.00
Awarded
February 13, 2026
Identifier
5R01AI191440-02
Research project to investigate TNF receptor signaling and IL-1 production in controlling Yersinia infection through pyogranuloma formation.
Description
This project aims to define TNF- and IL-1-dependent mechanisms that regulate pyogranuloma formation and control of Yersinia infection and dissemination dynamics, providing new insights into host defense against bacterial infection.