Award
National Institute of Allergy and Infectious Diseases 5R21AI190212-02
Mechanisms of central nervous system invasion by the Lyme disease spirochete, Borrelia burgdorferi
Recipient
University of South Alabama
Award Amount
$192,500.00
Ceiling
$192,500.00
Awarded
April 01, 2026
Identifier
5R21AI190212-02
Research grant awarded to study how Borrelia burgdorferi invades the central nervous system, aiming to identify entry sites and immune responses to inform new treatments.
Description
The bacterium that causes Lyme disease, Borrelia burgdorferi, can enter the central nervous system causing disease. Using a mouse model of Lyme disease, the proposed study will identify the site of entry as well as host immune responses that influence B. burgdorferi entry into the central nervous system, that could inform the development of novel prophylactics and/or therapeutics.