Award
National Institute of Diabetes and Digestive and Kidney Diseases 1R01DK146327-01
BMP2/6 ligand formation and function in development and iron homeostasis
Recipient
Massachusetts General Hospital, Boston, MA, United States
Award Amount
$813,961.00
Ceiling
$813,961.00
Awarded
January 26, 2026
Identifier
1R01DK146327-01
Research grant to study BMP2 and BMP6 proteins' roles in development and iron regulation, aiming to understand their molecular functions and impact on iron homeostasis.
Description
This project aims to investigate the formation and function of Bone Morphogenetic Proteins (BMPs), specifically BMP2 and BMP6, in development and iron homeostasis. The research will focus on how BMP2 and BMP6 heterodimers and homodimers contribute to the regulation of hepcidin and systemic iron balance. The study will utilize structural modeling, Xenopus embryos, human LEC-hepatocyte cell culture systems, and novel knock-in mice to elucidate the roles of BMP prodomains and proteolytic maturation processes.