Award
NIH Reporter #1R16CA315530-01
The Bit1 cell death pathway as a novel regulator of EGFR-TKI-induced apoptosis and resistance
Recipient
Xavier University of Louisiana
Award Amount
$150,000.00
Ceiling
$150,000.00
Awarded
August 20, 2026
Identifier
1R16CA315530-01
Research project funded by the National Cancer Institute to study the Bit1 cell death pathway as a novel approach to overcome resistance to EGFR-TKI treatments in non-small cell lung cancer.
Description
The project investigates the role of the Bit1 cell death pathway in overcoming resistance to EGFR-TKIs in non-small cell lung cancer (NSCLC). It aims to elucidate mechanisms by which Bit1 enhances EGFR-TKI sensitivity, define how it overcomes resistance, and evaluate its in vivo efficacy.