Award
National Institute on Aging 5R01AG082740-03
VPS13D, organelle contact, and cellular stress in models of disease
Recipient
University of Massachusetts Medical School Worcester
Award Amount
$410,375.00
Ceiling
$410,375.00
Awarded
July 29, 2025
Identifier
5R01AG082740-03
Research project funded by the National Institute on Aging to study the role of VPS13D in organelle contact and cellular stress related to neurodegenerative disease models.
Description
This project investigates the role of VPS13D mutation-associated mitochondria and ER contact in fibroblasts derived from patients and knockout mouse models. It aims to elucidate the impact on mitophagy, stress, and inflammation, contributing to understanding age-related neurodegenerative disorders.