Award
NIH Reporter #5P20GM130555-08
The role of adipocyte-drive inflammation and leptin pathway in pulmonary viral infections caused by SARS-CoV-2 and influenza A viruses
Recipient
Louisiana State University A&M College
Award Amount
$253,001.00
Ceiling
$253,001.00
Awarded
August 21, 2026
Identifier
5P20GM130555-08
This award supports research on how obesity-related inflammation and leptin signaling affect respiratory viral infections, aiming to develop targeted therapies for obese and diabetic patients.
Description
The project aims to elucidate the biological mechanisms by which metabolic diseases influence the pathogenicity of respiratory viral infections, focusing on the effects of dysfunctional adipocytes and the leptin pathway in shaping pulmonary innate responses to respiratory viral infections such as Influenza A and SARS-CoV-2. The study involves in vitro and in vivo methods to investigate leptin signaling and its impact on viral replication and lung injury, with the goal of identifying therapeutic targets for at-risk patients.