Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK107603-10
Mucosal Macrophages and Tertiary Lymphoid Structures in IBD
Recipient
University of Massachusetts Medical School Worcester
Award Amount
$546,982.00
Ceiling
$546,982.00
Awarded
February 20, 2025
Identifier
5R01DK107603-10
NIH-funded project investigating the role of mucosal macrophages in tertiary lymphoid structures formation in inflammatory bowel disease to identify mechanisms and therapeutic targets.
Description
This NIH-funded research project focuses on unraveling the mechanisms that drive tertiary lymphoid structures (TLS) formation and function in mouse models of inflammatory bowel disease (IBD) by targeting differentiation and function of mucosa-resident (CX3CR1hi) macrophages shown to induce TLS. The study aims to understand the cellular and molecular mechanisms underlying TLS formation and function in IBD, focusing on the role of CX3CR1hi macrophages and their regulation by TNF signaling, to provide insights into IBD pathogenesis and identify potential biomarkers and therapeutic targets.