Award
NIH Reporter #5R01DA064083-02
Transcriptional inactivation of the CNS HIV reservoir with Tat-targeting lipid nanoparticles.
Recipient
Edward P. Browne
Award Amount
$703,675.00
Ceiling
$703,675.00
Awarded
June 03, 2026
Identifier
5R01DA064083-02
Award for research project developing lipid nanoparticles targeting HIV Tat gene to inactivate CNS HIV reservoir, funded by NIH, duration 2025-2030.
Description
The project involves developing lipid nanoparticles containing Cas9/sgRNAs targeting the HIV Tat gene to prevent reactivation of the HIV reservoir in microglia. It includes in vivo testing in humanized mouse models and ex vivo testing in macaque brain samples. The project is funded by the NIH, with a focus on HIV cure research, and runs from August 15, 2025, to May 31, 2030.